Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Elevated arsenic exposure and efficient arsenic metabolism in indigenous women around Lake Poopó, Bolivia

Abstract : Elevated concentrations of inorganic arsenic, one of the most potent environmental toxicants and carcinogens, have been detected in well water around Lake Poopó, Bolivia. This study aimed to assess human exposure to arsenic in villages around Lake Poopó, and also to elucidate whether the metabolism and detoxification of arsenic in this population is as efficient as previously indicated in other Andean areas. We recruited 201 women from 10 villages around Lake Poopó. Arsenic exposure was determined as the sum concentration of arsenic metabolites (inorganic arsenic; monomethylarsonic acid, MMA; and dimethylarsinic acid, DMA) in urine (U-As), measured by HPLC-HG-ICP-MS. Efficiency of arsenic metabolism was assessed by the relative fractions of the urinary me-tabolites. The women had a wide variation in U-As (range 12-407 μg/L, median 65 μg/L) and a markedly efficient metabolism of arsenic with low %MMA (median 7.7%, range: 2.2-18%) and high %DMA (80%, range: 54-91%) in urine. In multivariable-adjusted linear regression models, ethnicity (Aymara-Quechua vs. Uru), body weight, fish consumption and tobacco smoking were associated with urinary arsenic metabolite fractions. On average, the Uru women had 2.5 lower % (percentage unit) iAs, 2.2 lower %MMA and 4.7 higher %DMA compared with the Aymara-Quechua women. Our study identified several factors that may predict these women's arsenic methyla-tion capacity, particularly ethnicity. Further studies should focus on mechanisms underlying these differences in arsenic metabolism efficiency, and its importance for the risk of arsenic-related health effects.
Liste complète des métadonnées

Littérature citée [60 références]  Voir  Masquer  Télécharger

https://hal.umontpellier.fr/hal-02064307
Contributeur : Jacques Gardon <>
Soumis le : vendredi 28 août 2020 - 11:06:14
Dernière modification le : samedi 29 août 2020 - 03:29:28
Archivage à long terme le : : dimanche 29 novembre 2020 - 12:23:10

Fichier

1-s2.0-S0048969718348289-main....
Publication financée par une institution

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Collections

Citation

Jessica de Loma, Noemi Tirado, Franz Ascui, Michael Levi, Marie Vahter, et al.. Elevated arsenic exposure and efficient arsenic metabolism in indigenous women around Lake Poopó, Bolivia. Science of the Total Environment, Elsevier, 2019, 657, pp.179-186. ⟨10.1016/j.scitotenv.2018.11.473⟩. ⟨hal-02064307⟩

Partager

Métriques

Consultations de la notice

129

Téléchargements de fichiers

43