Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells

Chaitali Ghosh 1 Mohammed Hossain Jesal Solanki Imad Najm 2 Nicola Marchi 3 Damir Janigro
1 LRI Cerebrovascular Research
2 Lerner Research Institute
3 IGF - Institut de Génomique Fonctionnelle
Abstract : Recent evidence suggests a metabolic contribution of cytochrome P450 enzymes (CYPs) to the drug-resistant phenotype in human epilepsy. However, the upstream molecular regulators of CYP in the epileptic brain remain understudied. We therefore investigated the expression and function of pregnane xenobiotic (PXR) and glucocorticoid (GR) nuclear receptors in endothelial cells established from post-epilepsy surgery brain samples.
Keywords : Drug resistance Epilepsy Neurovascular unit Nuclear Receptors
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https://hal.umontpellier.fr/hal-02060379
Contributeur : Sandrine Beraud <>
Soumis le : jeudi 7 mars 2019 - 13:21:34
Dernière modification le : dimanche 1 décembre 2019 - 09:04:03

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UNIV-MONTPELLIER | CNRS | BS

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Chaitali Ghosh, Mohammed Hossain, Jesal Solanki, Imad Najm, Nicola Marchi, et al.. Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells. Epilepsia, Wiley, 2017, 58 (4), pp.576-585. ⟨10.1111/epi.13703⟩. ⟨hal-02060379⟩

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