Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors

Abstract : The serotonin 2A (5-HT2A) receptor subtype continues to attract attention as a target for numerous psychoactive drugs including psychedelic hallucinogens, antidepressants, anxiolytics, and atypical antipsychotics. 5-HT2A receptors are a principal G protein-coupled receptor subtype mediating the excitatory effects of serotonin. Nonetheless, pre- vs postsynaptic localization of 5HT2A receptors, relative to glutamatergic synapses, has remained controversial. Here, we discuss recent findings highlighting the existence and roles of presynaptic 5-HT2A receptors in regulating glutamatergic transmission and cognition.
Liste complète des métadonnées
Contributeur : Sandrine Beraud <>
Soumis le : vendredi 22 février 2019 - 11:55:36
Dernière modification le : samedi 16 novembre 2019 - 01:27:44

Lien texte intégral




Carine Becamel, Coralie Berthoux, Alexander Barre, Philippe Marin. Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors. ACS Chemical Neuroscience, American Chemical Society (ACS), 2017, 8 (5), pp.897-899. ⟨10.1021/acschemneuro.6b00409⟩. ⟨hal-02045762⟩



Consultations de la notice