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Article Dans Une Revue ACS Chemical Neuroscience Année : 2017

Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors

Résumé

The serotonin 2A (5-HT2A) receptor subtype continues to attract attention as a target for numerous psychoactive drugs including psychedelic hallucinogens, antidepressants, anxiolytics, and atypical antipsychotics. 5-HT2A receptors are a principal G protein-coupled receptor subtype mediating the excitatory effects of serotonin. Nonetheless, pre- vs postsynaptic localization of 5HT2A receptors, relative to glutamatergic synapses, has remained controversial. Here, we discuss recent findings highlighting the existence and roles of presynaptic 5-HT2A receptors in regulating glutamatergic transmission and cognition.

Dates et versions

hal-02045762 , version 1 (22-02-2019)

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Citer

Carine Becamel, Coralie Berthoux, Alexander Barre, Philippe Marin. Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors. ACS Chemical Neuroscience, 2017, 8 (5), pp.897-899. ⟨10.1021/acschemneuro.6b00409⟩. ⟨hal-02045762⟩
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