Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors

Abstract : The serotonin 2A (5-HT2A) receptor subtype continues to attract attention as a target for numerous psychoactive drugs including psychedelic hallucinogens, antidepressants, anxiolytics, and atypical antipsychotics. 5-HT2A receptors are a principal G protein-coupled receptor subtype mediating the excitatory effects of serotonin. Nonetheless, pre- vs postsynaptic localization of 5HT2A receptors, relative to glutamatergic synapses, has remained controversial. Here, we discuss recent findings highlighting the existence and roles of presynaptic 5-HT2A receptors in regulating glutamatergic transmission and cognition.
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https://hal.umontpellier.fr/hal-02045762
Contributeur : Sandrine Beraud <>
Soumis le : vendredi 22 février 2019 - 11:55:36
Dernière modification le : mardi 28 mai 2019 - 14:12:02

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Carine Becamel, Coralie Berthoux, Alexander Barre, Philippe Marin. Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors. ACS Chemical Neuroscience, American Chemical Society (ACS), 2017, 8 (5), pp.897-899. ⟨10.1021/acschemneuro.6b00409⟩. ⟨hal-02045762⟩

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