Contrasted coevolutionary dynamics between a bacterial pathogen and its bacteriophages - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2014

Contrasted coevolutionary dynamics between a bacterial pathogen and its bacteriophages

Résumé

Many antagonistic interactions between hosts and their parasitesresult in coevolution. Although coevolution can drive diversity andspecificity within species, it is not known whether coevolutionarydynamics differ among functionally similar species. We presentevidence of coevolution within simple communities ofPseudomonasaeruginosaPAO1 and a panel of bacteriophages. Pathogen iden-tity affected coevolutionary dynamics. For five of six phages tested,time-shift assays revealed temporal peaks in bacterial resistance andphage infectivity, consistent with frequency-dependent selection(Red Queen dynamics). Two of the six phages also imposed addi-tional directional selection, resulting in strongly increased resistanceranges over the entire length of the experiment (ca. 60 generations).Cross-resistance to these two phages was very high, independent ofthe coevolutionary history of the bacteria. We suggest that coevo-lutionary dynamics are associated with the nature of the receptorused by the phage for infection. Our results shed light on thecoevolutionary process in simple communities and have practicalapplication in the control of bacterial pathogens through the evo-lutionary training of phages, increasing their virulence and effi-cacy as therapeutics or disinfectants.

Dates et versions

hal-02015233 , version 1 (12-02-2019)

Identifiants

Citer

Alex Betts, Oliver Kaltz, Michael Hochberg. Contrasted coevolutionary dynamics between a bacterial pathogen and its bacteriophages. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (30), pp.11109-11114. ⟨10.1073/pnas.1406763111⟩. ⟨hal-02015233⟩
63 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More