100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB

Abstract : Background: Gene duplication has led to a most remarkable adaptation involved in vertebrates' host-pathogen arms-race, the major histocompatibility complex (MHC). However, MHC duplication history is as yet poorly understood in non-mammalian vertebrates, including birds. Results: Here, we provide evidence for the evolution of two ancient avian MHC class IIB (MHCIIB) lineages by a duplication event prior to the radiation of all extant birds >100 million years ago, and document the role of concerted evolution in eroding the footprints of the avian MHCIIB duplication history. Results: Here, we provide evidence for the evolution of two ancient avian MHC class IIB (MHCIIB) lineages by a duplication event prior to the radiation of all extant birds >100 million years ago, and document the role of concerted evolution in eroding the footprints of the avian MHCIIB duplication history. Conclusions: Our results suggest that eroded footprints of gene duplication histories may mimic birth-death evolution and that in the avian MHC the presence of the two lineages may have been masked by elevated rates of concerted evolution in several taxa. Through the presence of a range of intermediate evolutionary stages along the homogenizing process of concerted evolution, the avian MHCIIB provides a remarkable illustration of the erosion of multigene family duplication history.
Type de document :
Article dans une revue
Liste complète des métadonnées

Littérature citée [49 références]  Voir  Masquer  Télécharger

https://hal.umontpellier.fr/hal-02010930
Contributeur : Philip Agnew <>
Soumis le : jeudi 7 février 2019 - 15:34:42
Dernière modification le : jeudi 12 septembre 2019 - 14:56:05
Document(s) archivé(s) le : mercredi 8 mai 2019 - 16:02:26

Fichier

document.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Citation

Julien Goebel, Marta Promerová, Francesco Bonadonna, Karen Mccoy, Céline Serbielle, et al.. 100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB. BMC Genomics, BioMed Central, 2017, 18, pp.460. ⟨10.1186/s12864-017-3839-7⟩. ⟨hal-02010930⟩

Partager

Métriques

Consultations de la notice

129

Téléchargements de fichiers

111