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Article Dans Une Revue OncoImmunology Année : 2015

CD39: A complementary target to immune checkpoints to counteract tumor-mediated immunosuppression

Résumé

We report that CD39-expressing-melanoma cells inhibited both T-cell proliferation and the generation of cytotoxic effectors in an adenosine-dependent manner, and that treatment with a CD39-blocking antibody alleviated tumor-mediated immunosuppression. Thus, blocking CD39 ectonucleotidase may represent a novel immunotherapeutic strategy to restore antitumor immunity.

Domaines

Cancer Immunologie

Dates et versions

hal-01976632 , version 1 (10-01-2019)

Identifiants

Citer

Jérémy Bastid, Gilles Alberici, Armand Bensussan, Jean-François Eliaou. CD39: A complementary target to immune checkpoints to counteract tumor-mediated immunosuppression. OncoImmunology, 2015, 4 (5), pp.e1003015. ⟨10.1080/2162402X.2014.1003015⟩. ⟨hal-01976632⟩
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