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Article Dans Une Revue Progress in Molecular Biology and Translational Science Année : 2014

Zebrafish as a model of cardiac disease

R. N. Wilkinson
  • Fonction : Auteur
F. J. Van Eeden
  • Fonction : Auteur

Résumé

The zebrafish has been rapidly adopted as a model for cardiac development and disease. The transparency of the embryo, its limited requirement for active oxygen delivery, and ease of use in genetic manipulations and chemical exposure have made it a powerful alternative to rodents. Novel technologies like TALEN/CRISPR-mediated genome engineering and advanced imaging methods will only accelerate its use. Here, we give an overview of heart development and function in the fish and highlight a number of areas where it is most actively contributing to the understanding of cardiac development and disease. We also review the current state of research on a feature that we only could wish to be conserved between fish and human; cardiac regeneration.
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Dates et versions

hal-01950139 , version 1 (10-12-2018)

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R. N. Wilkinson, Chris Jopling, F. J. Van Eeden. Zebrafish as a model of cardiac disease. Progress in Molecular Biology and Translational Science, 2014, 124, pp.65--91. ⟨10.1016/B978-0-12-386930-2.00004-5⟩. ⟨hal-01950139⟩
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