Graduated compression stockings to treat acute leg pain associated with proximal DVT. A randomised controlled trial. - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Thrombosis and Haemostasis Année : 2014

Graduated compression stockings to treat acute leg pain associated with proximal DVT. A randomised controlled trial.

Susan Kahn
Stan Shapiro
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Thierry Ducruet
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Philip Wells
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Michael Kovacs
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David Anderson
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Vicky Tagalakis
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David Morrison
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Susan Solymoss
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Marie-José Miron
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Erik Yeo
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Reginald Smith
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Sam Schulman
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Jeannine Kassis
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Clive Kearon
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Isabelle Chagnon
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Turnly Wong
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Christine Demers
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Rajendar Hanmiah
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Scott Kaatz
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Rita Selby
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Suman Rathbun
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Sylvie Desmarais
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Lucie Opatrny
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Thomas Ortel
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Jeffrey Ginsberg
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Résumé

Acute deep venous thrombosis (DVT) causes leg pain. Elastic compression stockings (ECS) have potential to relieve DVT-related leg pain by diminishing the diameter of distended veins and increasing venous blood flow. It was our objective to determine whether ECS reduce leg pain in patients with acute DVT. We performed a secondary analysis of the SOX Trial, a multicentre randomised placebo controlled trial of active ECS versus placebo ECS to prevent the post-thrombotic syndrome.The study was performed in 24 hospital centres in Canada and the U.S. and included 803 patients with a first episode of acute proximal DVT. Patients were randomised to receive active ECS (knee length, 30-40 mm Hg graduated pressure) or placebo ECS (manufactured to look identical to active ECS, but lacking therapeutic compression). Study outcome was leg pain severity assessed on an 11-point numerical pain rating scale (0, no pain; 10, worst possible pain) at baseline, 14, 30 and 60 days after randomisation. Mean age was 55 years and 60% were male. In active ECS patients (n=409), mean (SD) pain severity at baseline and at 60 days were 5.18 (3.29) and 1.39 (2.19), respectively, and in placebo ECS patients (n=394) were 5.38 (3.29) and 1.13 (1.86), respectively. There were no significant differences in pain scores between groups at any assessment point, and no evidence for subgroup interaction by age, sex or anatomical extent of DVT. Results were similar in an analysis restricted to patients who reported wearing stockings every day. In conclusion, ECS do not reduce leg pain in patients with acute proximal DVT.
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Dates et versions

hal-01945647 , version 1 (05-12-2018)

Identifiants

Citer

Susan Kahn, Stan Shapiro, Thierry Ducruet, Philip Wells, Marc Rodger, et al.. Graduated compression stockings to treat acute leg pain associated with proximal DVT. A randomised controlled trial.. Thrombosis and Haemostasis, 2014, 112 (6), pp.1137-1141. ⟨10.1160/TH14-05-0430⟩. ⟨hal-01945647⟩
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