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Article Dans Une Revue DNA and Cell Biology Année : 2018

Flaviviruses Produce a Subgenomic Flaviviral RNA That Enhances Mosquito Transmission

Résumé

Mosquito-borne flaviviruses (MBFVs) are a global public health burden. MBFVs have several unique 3′UTR structures that inhibit the host RNA decay machinery to produce subgenomic flaviviral RNAs (sfRNAs). Number of sfRNA species and their relative quantities are dependent on the 3′UTR tertiary structures and can vary between tissues. Two recent in vivo studies demonstrated that sfRNA enhances mosquito transmission, resulting in increased infection rate of saliva. Transmission efficiency is determined by the immune response. First evidence points to sfRNA interference with the Toll and RNAi immune pathways. However, a more complex picture that includes flexibility in sfRNA production and interaction with immune-related proteins remains to be explored.
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Dates et versions

hal-01937761 , version 1 (28-11-2018)

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Shih-Chia Yeh, Julien Pompon. Flaviviruses Produce a Subgenomic Flaviviral RNA That Enhances Mosquito Transmission. DNA and Cell Biology, 2018, 37 (3), pp.154 - 159. ⟨10.1089/dna.2017.4059⟩. ⟨hal-01937761⟩
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