Cellular senescence impact on immune cell fate and function - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Aging Cell Année : 2016

Cellular senescence impact on immune cell fate and function

Résumé

Cellular senescence occurs not only in cultured fibroblasts, but also in undifferentiated and specialized cells from various tissues of all ages, in vitro and in vivo. Here, we review recent findings on the role of cellular senescence in immune cell fate decisions in macrophage polarization, natural killer cell phenotype, and following T-lymphocyte activation. We also introduce the involvement of the onset of cellular senescence in some immune responses including T-helper lymphocyte-dependent tissue homeostatic functions and T-regulatory cell-dependent suppressive mechanisms. Altogether, these data propose that cellular senescence plays a wide-reaching role as a homeostatic orchestrator.
Fichier principal
Vignette du fichier
IRMB 6_P48_Cellular senescence impact on immune cell fate and function_acel.12455.pdf (102.99 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-01834241 , version 1 (10-03-2021)

Licence

Paternité

Identifiants

Citer

Rita Vicente, Anne-Laure Mausset-Bonnefont, Christian Jorgensen, Pascale Louis-Plence, Jean-Marc Brondello. Cellular senescence impact on immune cell fate and function. Aging Cell, 2016, 15 (3), pp.400 - 406. ⟨10.1111/acel.12455⟩. ⟨hal-01834241⟩
75 Consultations
56 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More