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Epinephrine and short-term survival in cardiogenic shock: an individual data meta-analysis of 2583 patients

Valentine Léopold 1, 2 Etienne Gayat 2, 1 Romain Pirracchio 3 Jindrich Spinar 4, 5 Jiri Parenica 4, 5 Tuukka Tarvasmäki 6, 7, 8 Johan Lassus 6, 7 Veli-Pekka Harjola 6, 7 Sébastien Champion 9 Faiez Zannad 10 Serafina Valente 11 Philip Urban 12 Horng-Ruey Chua 13, 14, 15, 16, 17 Rinaldo Bellomo 13, 14, 15, 16 Batric Popovic 18 Dagmar Ouweneel 19 José Henriques 19 Gregor Simonis 20, 21 Bruno Levy 22, 23 Antoine Kimmoun 22, 23 Philippe Gaudard 24, 25 Mir Babar Basir 26 Andrej Markota 27 Christoph Adler 28 Hannes Reuter 28 Alexandre Mebazaa 1, 2, 29 Tahar Chouihed 10, 1, 2, 30, 22
Abstract : Objective: Catecholamines have been the mainstay of pharmacological treatment of cardiogenic shock (CS). Recently, use of epinephrine has been associated with detrimental outcomes. In the present study we aimed to evaluate the association between epinephrine use and short-term mortality in all-cause CS patients. Design: We performed a meta-analysis of individual data with prespecified inclusion criteria: (1) patients in non-surgical CS treated with inotropes and/or vasopressors and (2) at least 15% of patients treated with epinephrine administrated alone or in association with other inotropes/vasopressors. The primary outcome was short-term mortality. Measurements and results: Fourteen published cohorts and two unpublished data sets were included. We studied 2583 patients. Across all cohorts of patients, the incidence of epinephrine use was 37% (17-76%) and short-term mortality rate was 49% (21-69%). A positive correlation was found between percentages of epinephrine use and short-term mortality in the CS cohort. The risk of death was higher in epinephrine-treated CS patients (OR [CI] = 3.3 [2.8-3.9]) compared to patients treated with other drug regimens. Adjusted mortality risk remained striking in epinephrine-treated patients (n = 1227) (adjusted OR = 4.7 [3.4-6.4]). After propensity score matching, two sets of 338 matched patients were identified and epinephrine use remained associated with a strong detrimental impact on short-term mortality (OR = 4.2 [3.0-6.0]). Conclusions: In this very large cohort, epinephrine use for hemodynamic management of CS patients is associated with a threefold increase of risk of death.
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Soumis le : vendredi 1 mai 2020 - 11:07:48
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Valentine Léopold, Etienne Gayat, Romain Pirracchio, Jindrich Spinar, Jiri Parenica, et al.. Epinephrine and short-term survival in cardiogenic shock: an individual data meta-analysis of 2583 patients. Intensive Care Medicine, Springer Verlag, In press, 44 (6), pp.847-856. ⟨10.1007/s00134-018-5222-9⟩. ⟨hal-01809259⟩



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