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Article Dans Une Revue Journal of Clinical Immunology Année : 2017

Idiopathic Non-histaminergic Angioedema: Successful Treatment with Omalizumab in Five Patients

Résumé

Idiopathic non-histaminergic acquired angioedema (InH-AAE) is a rare disease characterized by AE resistant to antihistamines and a chronic course. We report five new cases of InH-AAE (two women and three men) with a rapid and dramatic response to the anti-immunoglobulin-E antibody omalizumab. In our literature review, we found 13 other relevant cases with a good response to this treatment. Overall, in 6 out of 18 patients, the doses of omalizumab required to prevent recurrences of attacks were higher than the licensed dose for chronic urticaria. No significant adverse effects have been reported.
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Dates et versions

hal-01802498 , version 1 (29-05-2018)

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Citer

Charles Faisant, Aurélie Du Thanh, Catherine Mansard, Alban Deroux, Isabelle Boccon-Gibod, et al.. Idiopathic Non-histaminergic Angioedema: Successful Treatment with Omalizumab in Five Patients. Journal of Clinical Immunology, 2017, 37 (1), pp.80 - 84. ⟨10.1007/s10875-016-0345-7⟩. ⟨hal-01802498⟩
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