The second phase of insulin secretion in non-diabetic islet-grafted recipients is altered and can predict graft outcome

Abstract : Islet transplantation (IT) can treat patients with severely unstable type 1 diabetes. Pre-hepatic kinetics of insulin-secretion (ISec) in two phases can be calculated by C-peptide levels during meal tests. We propose to describe insulin secretion profile after a Mixed-Meal Tolerance Test (MMTT) in IT patients and to determine whether the calculated indexes of ISec can predict graft outcome.
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https://hal.umontpellier.fr/hal-01797358
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Soumis le : mardi 22 mai 2018 - 15:06:33
Dernière modification le : mercredi 29 mai 2019 - 11:46:05

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Orianne Villard, Jean Frédéric Brun, Lisa Bories, Nicolas Molinari, Pierre Yves Benhamou, et al.. The second phase of insulin secretion in non-diabetic islet-grafted recipients is altered and can predict graft outcome. Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2018, ⟨10.1210/jc.2017-01342⟩. ⟨hal-01797358⟩

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