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L-type Ca v 1.3 channels regulate ryanodine receptor-dependent Ca 2+ release during sino-atrial node pacemaker activity

Abstract : Sino-atrial node (SAN) automaticity is an essential mechanism of heart rate generation that is still not completely understood. Recent studies highlighted the importance of intracellular Ca(2+) ([Ca(2+)]i) dynamics during SAN pacemaker activity. Nevertheless, the functional role of voltage-dependent L-type Ca(2+) channels in controlling SAN [Ca(2+)]i release is largely unexplored. Since Cav1.3 is the predominant L-type Ca(2+) channel isoform in SAN cells, we studied [Ca(2+)]i dynamics in isolated cells and ex vivo SAN preparations explanted from wild-type (WT) and Cav1.3 knockout (KO) mice (Cav1.3(-/-)).
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https://hal.umontpellier.fr/hal-01792471
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Soumis le : samedi 28 mars 2020 - 11:58:31
Dernière modification le : jeudi 7 mai 2020 - 22:42:04

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Angelo Giovanni Torrente, Pietro Mesirca, Patricia Neco, Riccardo Rizzetto, Stefan Dübel, et al.. L-type Ca v 1.3 channels regulate ryanodine receptor-dependent Ca 2+ release during sino-atrial node pacemaker activity. Cardiovascular Research, Oxford University Press (OUP), 2016, 109 (3), pp.451-461. ⟨10.1093/cvr/cvw006⟩. ⟨hal-01792471⟩

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