L-type Ca v 1.3 channels regulate ryanodine receptor-dependent Ca 2+ release during sino-atrial node pacemaker activity

Sino-atrial node (SAN) automaticity is an essential mechanism of heart rate generation that is still not completely understood. Recent studies highlighted the importance of intracellular Ca(2+) ([Ca(2+)]i) dynamics during SAN pacemaker activity. Nevertheless, the functional role of voltage-dependent L-type Ca(2+) channels in controlling SAN [Ca(2+)]i release is largely unexplored. Since Cav1.3 is the predominant L-type Ca(2+) channel isoform in SAN cells, we studied [Ca(2+)]i dynamics in isolated cells and ex vivo SAN preparations explanted from wild-type (WT) and Cav1.3 knockout (KO) mice (Cav1.3(-/-)).

Mots clés

Cav1.3 Ca2+ dynamics Sino-atrial node Pacemaker activity L-type Ca2+ channels

Domaines

Cardiologie et système cardiovasculaire Biochimie, Biologie Moléculaire

Fichier principal

2016 Torrente et al., L type calcium1.3 chanel.pdf (47.21 Mo)

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Dominique MORNET : Connectez-vous pour contacter le contributeur

https://hal.umontpellier.fr/hal-01792471

Soumis le : samedi 28 mars 2020-11:58:31

Dernière modification le : jeudi 29 février 2024-09:14:04

Dates et versions

hal-01792471 , version 1 (28-03-2020)

Identifiants

HAL Id : hal-01792471 , version 1
DOI : 10.1093/cvr/cvw006
PUBMED : 26786159

Citer

Angelo Torrente, Pietro Mesirca, Patricia Neco, Riccardo Rizzetto, Stefan Dübel, et al.. L-type Ca v 1.3 channels regulate ryanodine receptor-dependent Ca 2+ release during sino-atrial node pacemaker activity. Cardiovascular Research, 2016, 109 (3), pp.451-461. ⟨10.1093/cvr/cvw006⟩. ⟨hal-01792471⟩

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