Non-enzymatic cyclic oxygenated metabolites of adrenic, docosahexaenoic, eicosapentaenoic and α-linolenic acids; bioactivities and potential use as biomarkers - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids Année : 2015

Non-enzymatic cyclic oxygenated metabolites of adrenic, docosahexaenoic, eicosapentaenoic and α-linolenic acids; bioactivities and potential use as biomarkers

Résumé

Cyclic oxygenated metabolites are formed in vivo through non-enzymatic free radical reaction of n-6 and n-3 polyunsaturated fatty acids (PUFAs) such as arachidonic (ARA C20:4 n-6), adrenic (AdA 22:4 n-6), α-linolenic (ALA 18:3 n-3), eicosapentaenoic (EPA 20:5 n-3) and docosahexaenoic (DHA 22:6 n-3) acids. These cyclic compounds are known as isoprostanes, neuroprostanes, dihomo-isoprostanes and phytoprostanes. Evidence has emerged for their use as biomarkers of oxidative stress and, more recently, the n-3PUFA-derived compounds have been shown to mediate bioactivities as secondary messengers. Accordingly, this review will focus on the cyclic oxygenated metabolites generated from AdA, ALA, EPA and DHA. This article is part of a Special Issue entitled "Oxygenated metabolism of PUFA: analysis and biological relevance"
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Dates et versions

hal-01764624 , version 1 (14-09-2018)

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Jean-Marie Galano, Jetty Chung-Yung Lee, Cécile Gladine, Blandine Comte, Jean-Yves Le Guennec, et al.. Non-enzymatic cyclic oxygenated metabolites of adrenic, docosahexaenoic, eicosapentaenoic and α-linolenic acids; bioactivities and potential use as biomarkers. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2015, 1851 (4), pp.446 - 455. ⟨10.1016/j.bbalip.2014.11.004⟩. ⟨hal-01764624⟩
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