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Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2024

Self-assembled porphyrin–peptide cages for photodynamic therapy

Résumé

The development of photodynamic therapy requires access to smart photosensitizers which combine appropriate photophysical and biological properties. Interestingly, supramolecular and dynamic covalent chemistries have recently shown their ability to produce novel architectures and responsive systems through simple self-assembly approaches. Herein, we report the straightforward formation of porphyrin–peptide conjugates and cage compounds which feature on their surface chemical groups promoting cell uptake and specific organelle targeting. We show that they self-assemble, in aqueous media, into positively-charged nanoparticles which generate singlet oxygen upon green light irradiation, while also undergoing a chemically-controlled disassembly due to the presence of reversible covalent linkages. Finally, the biological evaluation in cells revealed that they act as effective photosensitizers and promote synergistic effects in combination with Doxorubicin.
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Dates et versions

hal-04560453 , version 1 (26-04-2024)

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Chandramouli Ghosh, Lamiaa Ali, Yannick Bessin, Sébastien Clément, Sébastien Richeter, et al.. Self-assembled porphyrin–peptide cages for photodynamic therapy. Organic & Biomolecular Chemistry, 2024, 22 (7), pp.1484-1494. ⟨10.1039/d3ob01887c⟩. ⟨hal-04560453⟩
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