Probing the Use of Triphenyl Phosphonium Cation for Mitochondrial Nucleoside Delivery - Université de Montpellier
Article Dans Une Revue ACS Medicinal Chemistry Letters Année : 2024

Probing the Use of Triphenyl Phosphonium Cation for Mitochondrial Nucleoside Delivery

Résumé

Herein, we report the design, the synthesis, and the study of novel triphenyl phosphonium-based nucleoside conjugates. 2′-Deoxycytidine was chosen as nucleosidic cargo, as it allows the introduction of fluorescein on the exocyclic amine of the nucleobase and grafting of the vector was envisaged through the formation of a biolabile ester bond with the hydroxyl function at the 5′-position. Compound 3 was identified as a potential nucleoside prodrug, showing ability to be internalized efficiently into cells and to be co-localized with mitochondria.
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Dates et versions

hal-04560353 , version 1 (30-10-2024)

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Mathis Guiraud, Lamiaa Mohamed Ahmed Ali, Emma Gabrieli-Magot, Laure Lichon, Morgane Daurat, et al.. Probing the Use of Triphenyl Phosphonium Cation for Mitochondrial Nucleoside Delivery. ACS Medicinal Chemistry Letters, 2024, 15 (3), pp.418-422. ⟨10.1021/acsmedchemlett.3c00568⟩. ⟨hal-04560353⟩
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