Ball‐Milling to Access Dinucleoside Polyphosphates and Analogues - Université de Montpellier
Article Dans Une Revue Advanced Synthesis and Catalysis Année : 2024

Ball‐Milling to Access Dinucleoside Polyphosphates and Analogues

Résumé

Dinucleoside 5’,5’‐polyphosphates (Np n Ns) play essential roles in various biological processes. Access to these high value‐added compounds, while avoiding the many drawbacks of solution phase synthesis, is a challenge that has been overcome thanks to mechanochemistry. A straightforward solid‐state synthesis based on activation of phosphate or pyrophosphate sodium salts to their diimidazolides, followed by coupling with commercially available nucleotides, under air conditions, gave symmetrical Np n Ns. The scope ranged from Np 3 Ns to highly challenging Np 6 Ns. The methodology has also been implemented using medronic acid and imidodiphosphate to obtain Np n Ns analogues, some of which are unprecedented.

Domaines

Chimie
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Dates et versions

hal-04549887 , version 1 (15-07-2024)

Identifiants

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Valentin Navarro, Florian Vasco, Xavier Bantreil, Frédéric Lamaty, Suzanne Peyrottes, et al.. Ball‐Milling to Access Dinucleoside Polyphosphates and Analogues. Advanced Synthesis and Catalysis, 2024, 366, pp.1776-1781. ⟨10.1002/adsc.202400057⟩. ⟨hal-04549887⟩
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