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Article Dans Une Revue Chemical Science Année : 2024

Dynamic covalent synthesis


Dynamic covalent synthesis aims to precisely control the assembly of simple building blocks linked by reversible covalent bonds to generate a single, structurally complex, product. In recent years, considerable progress in the programmability of dynamic covalent systems has enabled easy access to a broad range of assemblies, including macrocycles, shape-persistent cages, unconventional foldamers and mechanically-interlocked species (catenanes, knots, etc.). The reversibility of the covalent linkages can be either switched off to yield stable, isolable products or activated by specific physico-chemical stimuli, allowing the assemblies to adapt and respond to environmental changes in a controlled manner. This activatable dynamic property makes dynamic covalent assemblies particularly attractive for the design of complex matter, smart chemical systems, out-of-equilibrium systems, and molecular devices.



Dates et versions

hal-04549240 , version 1 (17-04-2024)



Fabien Cougnon, Artur Stefankiewicz, Sébastien Ulrich. Dynamic covalent synthesis. Chemical Science, 2024, 15 (3), pp.879-895. ⟨10.1039/d3sc05343a⟩. ⟨hal-04549240⟩
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