Gamma irradiation-induced offspring masculinization is associated with epigenetic changes in female zebrafish - Université de Montpellier
Article Dans Une Revue Ecotoxicology and Environmental Safety Année : 2024

Gamma irradiation-induced offspring masculinization is associated with epigenetic changes in female zebrafish

Résumé

Sex ratio variation is a key topic in ecology, because of its direct effects on population dynamics and thus, on animal conservation strategies. Among factors affecting sex ratio, types of sex determination systems have a central role, since some species could have a sex determined by genetic factors, environmental factors or a mix of those two. Yet, most studies on the factors affecting sex determination have focused on temperature or endocrinedisrupting chemicals (EDCs), and much less is known regarding other factors. Exposure to gamma irradiation was found to trigger offspring masculinization in zebrafish. Here we aimed at deciphering the potential mechanisms involved, by focusing on stress (i.e. cortisol) and epigenetic regulation of key genes involved in sex differentiation in fish. Cortisol levels in exposed and control (F0) zebrafish females' gonads were similar. However, irradiation increased the DNA methylation level of foxl2a and cyp19a1a in females of the F0 and F1 generation, respectively, while no effects were detected in testis. Overall, our results suggest that parental exposure could alter offspring sex ratio, at least in part by inducing methylation changes in ovaries.
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Dates et versions

hal-04761706 , version 1 (31-10-2024)

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Noemie Guirandy, Olivier Simon, Benjamin Geffroy, Guillemine Daffe, Flore Daramy, et al.. Gamma irradiation-induced offspring masculinization is associated with epigenetic changes in female zebrafish. Ecotoxicology and Environmental Safety, 2024, 269, pp.115790. ⟨10.1016/j.ecoenv.2023.115790⟩. ⟨hal-04761706⟩
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