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Article Dans Une Revue Cancer Biomarkers Année : 2023

Urinary VOCs as biomarkers of early stage lung tumour development in mice

Résumé

Background: Lung cancer is the primary cause of cancer-induced death. In addition to prevention and improved treatment, it has increasingly been established that early detection is critical to successful remission. Objective: The aim of this study was to identify volatile organic compounds (VOCs) in urine that could help diagnose mouse lung cancer at an early stage of its development. Methods: We analysed the VOC composition of urine in a genetically engineered lung adenocarcinoma mouse model with oncogenic EGFR doxycycline-inducible lung-specific expression. We compared the urinary VOCs of 10 cancerous mice and 10 healthy mice (controls) before and after doxycycline induction, every two weeks for 12 weeks, until full-blown carcinomas appeared. We used SPME fibres and gas chromatographymass spectrometry to detect variations in cancer-related urinary VOCs over time. Results: This study allowed us to identify eight diagnostic biomarkers that help discriminate early stages of cancer tumour development (i.e., before MRI imaging techniques could identify it). Conclusion: The analysis of mice urinary VOCs have shown that cancer can induce changes in odour profiles at an early stage of cancer development, opening a promising avenue for early diagnosis of lung cancer in other models.
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hal-04283490 , version 1 (13-11-2023)

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Flora Gouzerh, Gwenaëlle Vigo, Laurent Dormont, Bruno Buatois, Maxime Hervé, et al.. Urinary VOCs as biomarkers of early stage lung tumour development in mice. Cancer Biomarkers, In press, Pre-Press, pp.1-23. ⟨10.3233/CBM-230070⟩. ⟨hal-04283490⟩
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