Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue RSC Medicinal Chemistry Année : 2022

Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model

Philipp Spatz
Thomas Zimmermann
Sophie Steinmüller
Julian Hofmann
  • Fonction : Auteur
Tangui Maurice
Mécanismes moléculaires dans les démences neurodégénératives
Michael Decker

Résumé

Benzimidazole-based inhibitors of butyrylcholinesterase were designed and tested for their activity and selectivity in vitro , leading to compound (11d) that attenuated Aβ 25-35 -induced learning impairments in an Alzheimer's disease mouse model.

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Sciences du Vivant [q-bio]

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https://hal.umontpellier.fr/hal-04267435

Soumis le : mercredi 1 novembre 2023-16:41:56

Dernière modification le : vendredi 19 avril 2024-16:19:00

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hal-04267435 , version 1 (01-11-2023)

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Philipp Spatz, Thomas Zimmermann, Sophie Steinmüller, Julian Hofmann, Tangui Maurice, et al.. Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model. RSC Medicinal Chemistry, 2022, 13 (8), pp.944-954. ⟨10.1039/d2md00087c⟩. ⟨hal-04267435⟩

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