Integrative studies of 3D genome organization and chromatin structure - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Current Opinion in Structural Biology Année : 2022

Integrative studies of 3D genome organization and chromatin structure

Marco Di Stefano
Giacomo Cavalli

Résumé

The structural organization of the genome is emerging as a crucial regulator of the cell state, affecting gene transcription, DNA replication, and repair. Over the last twenty years, increasing evidence prompted the development of new experimental techniques to study genome structure. In parallel with the complexity of the novel techniques, computational approaches have become an essential tool in any structural genomics laboratory to analyze and model the data. For biologists to be able to apply the most appropriate modeling approach, it is fundamental to understand the conceptual bases of distinct methods and the insights they can provide. Here, we will discuss recent advances that were possible thanks to 3D genome modeling, discuss their limitations and highlight future perspectives.
Fichier principal
Vignette du fichier
1-s2.0-S0959440X22001725-main.pdf (1.4 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Licence : CC BY NC ND - Paternité - Pas d'utilisation commerciale - Pas de modification

Dates et versions

hal-04114081 , version 1 (01-06-2023)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Marco Di Stefano, Giacomo Cavalli. Integrative studies of 3D genome organization and chromatin structure. Current Opinion in Structural Biology, 2022, 77, pp.102493. ⟨10.1016/j.sbi.2022.102493⟩. ⟨hal-04114081⟩
5 Consultations
17 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More