3D printing of cellulose nanocrystals based composites to build robust biomimetic scaffolds for bone tissue engineering - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Scientific Reports Année : 2022

3D printing of cellulose nanocrystals based composites to build robust biomimetic scaffolds for bone tissue engineering

Résumé

Abstract Cellulose nanocrystals (CNC) are drawing increasing attention in the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability and excellent mechanical properties. Herein, we fabricated using fused deposition modelling technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii . Scanning electron microscopy revealed that the printed scaffolds exhibit interconnected pores with an estimated average pore size of approximately 400 µm. Incorporating 3% (w/w) of CNC into the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%) and wettability (water contact angle decreased by ~ 17%). The mineralization process of printed scaffolds using simulated body fluid was validated and nucleation of hydroxyapatite confirmed. Additionally, cytocompatibility tests revealed that PLA and CNC-based PLA scaffolds are non-toxic and compatible with bone cells. Our design, based on rapid 3D printing of PLA/CNC composites, combines the ability to control the architecture and provide improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine.
Fichier principal
Vignette du fichier
2022 NGatta et al Sci Rep 3D PLA NC.pdf (2.79 Mo) Télécharger le fichier
41598_2022_25652_MOESM1_ESM.pdf (841.91 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04109785 , version 1 (30-05-2023)

Licence

Paternité

Identifiants

Citer

Kanga Marius N’gatta, Habib Belaid, Joelle El Hayek, Edja Florentin Assanvo, Marilyn Kajdan, et al.. 3D printing of cellulose nanocrystals based composites to build robust biomimetic scaffolds for bone tissue engineering. Scientific Reports, 2022, 12 (1), pp.21244. ⟨10.1038/s41598-022-25652-x⟩. ⟨hal-04109785⟩
16 Consultations
14 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More