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Article Dans Une Revue (Article De Synthèse) Current Opinion in Genetics and Development Année : 2023

Contributions of 3D chromatin structure to cell-type specific gene regulation

Marie Schaeffer
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Marcelo Nollmann

Résumé

Eukaryotic genomes are organized in 3D in a multi-scale manner, and different mechanisms acting at each of these scales can contribute to transcriptional regulation. However, the large single-cell variability in 3D chromatin structures represent a challenge to understand how transcription may be differentially regulated between cell types in a robust and efficient manner. Here, we describe the different mechanisms by which 3D chromatin structure was shown to contribute to cell type-specific transcriptional regulation. Excitingly, several novel methodologies able to measure 3D chromatin conformation and transcription in single cells in their native tissue context, or to detect the dynamics of cis-regulatory interactions, are starting to allow quantitative dissection of chromatin structure noise and relate it to how transcription may be regulated between different cell types and cell states.
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Dates et versions

hal-03974114 , version 1 (07-10-2023)

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Marie Schaeffer, Marcelo Nollmann. Contributions of 3D chromatin structure to cell-type specific gene regulation. Current Opinion in Genetics and Development, In press, 79, pp.102032. ⟨10.1016/j.gde.2023.102032⟩. ⟨hal-03974114⟩
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