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Article Dans Une Revue ACS Applied Bio Materials Année : 2022

Fabrication of Radio-Opaque and Macroporous Injectable Calcium Phosphate Cement

Jonathan Barés
Vincent Huon
David Cornu

Résumé

The aim of this work was the development of injectable radio-opaque and macroporous calcium phosphate cement (CPC) to be used as a bone substitute for the treatment of pathologic vertebral fractures. A CPC was first rendered radio-opaque by the incorporation of zirconium dioxide (ZrO2). In order to create macroporosity, poly lactic-co-glycolic acid (PLGA) microspheres around 100 μm were homogeneously incorporated into the CPC as observed by scanning electron microscopy. Physicochemical analyses by X-ray diffraction and Fourier transform infrared spectroscopy confirmed the brushite phase of the cement. The mechanical properties of the CPC/PLGA cement containing 30% PLGA (wt/wt) were characterized by a compressive strength of 2 MPa and a Young’s modulus of 1 GPa. The CPC/PLGA exhibited initial and final setting times of 7 and 12 min, respectively. Although the incorporation of PLGA microspheres increased the force necessary to inject the cement and decreased the percentage of injected mass as a function of time, the CPC/PLGA appeared fully injectable at 4 min. Moreover, in comparison with CPC, CPC/PLGA showed a full degradation in 6 weeks (with 100% mass loss), and this was associated with an acidification of the medium containing the CPC/PLGA sample (pH of 3.5 after 6 weeks). A cell viability test validated CPC/PLGA biocompatibility, and in vivo analyses using a bone defect assay in the caudal vertebrae of Wistar rats showed the good opacity of the CPC through the tail and a significant increased degradation of the CPC/PLGA cement a month after implantation. In conclusion, this injectable CPC scaffold appears to be an interesting material for bone substitution.
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Dates et versions

hal-03851896 , version 1 (14-11-2022)

Identifiants

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Habib Belaid, Carole Barou, Pierre-Yves Collart Dutilleul, Alban Desoutter, Marilyn Kajdan, et al.. Fabrication of Radio-Opaque and Macroporous Injectable Calcium Phosphate Cement. ACS Applied Bio Materials, 2022, 5 (6), pp.3075-3085. ⟨10.1021/acsabm.2c00345⟩. ⟨hal-03851896⟩
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