Fabrication of Radio-Opaque and Macroporous Injectable Calcium Phosphate Cement - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue ACS Applied Bio Materials Année : 2022

Fabrication of Radio-Opaque and Macroporous Injectable Calcium Phosphate Cement

Jonathan Barés
Vincent Huon
David Cornu


The aim of this work was the development of injectable radio-opaque and macroporous calcium phosphate cement (CPC) to be used as a bone substitute for the treatment of pathologic vertebral fractures. A CPC was first rendered radio-opaque by the incorporation of zirconium dioxide (ZrO2). In order to create macroporosity, poly lactic-co-glycolic acid (PLGA) microspheres around 100 μm were homogeneously incorporated into the CPC as observed by scanning electron microscopy. Physicochemical analyses by X-ray diffraction and Fourier transform infrared spectroscopy confirmed the brushite phase of the cement. The mechanical properties of the CPC/PLGA cement containing 30% PLGA (wt/wt) were characterized by a compressive strength of 2 MPa and a Young’s modulus of 1 GPa. The CPC/PLGA exhibited initial and final setting times of 7 and 12 min, respectively. Although the incorporation of PLGA microspheres increased the force necessary to inject the cement and decreased the percentage of injected mass as a function of time, the CPC/PLGA appeared fully injectable at 4 min. Moreover, in comparison with CPC, CPC/PLGA showed a full degradation in 6 weeks (with 100% mass loss), and this was associated with an acidification of the medium containing the CPC/PLGA sample (pH of 3.5 after 6 weeks). A cell viability test validated CPC/PLGA biocompatibility, and in vivo analyses using a bone defect assay in the caudal vertebrae of Wistar rats showed the good opacity of the CPC through the tail and a significant increased degradation of the CPC/PLGA cement a month after implantation. In conclusion, this injectable CPC scaffold appears to be an interesting material for bone substitution.
Fichier principal
Vignette du fichier
ACS Applied Bio Materials, 2022, 5, 6, 3075–3085.pdf (1.35 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03851896 , version 1 (14-11-2022)



Habib Belaid, Carole Barou, Pierre-Yves Collart Dutilleul, Alban Desoutter, Marilyn Kajdan, et al.. Fabrication of Radio-Opaque and Macroporous Injectable Calcium Phosphate Cement. ACS Applied Bio Materials, 2022, 5 (6), pp.3075-3085. ⟨10.1021/acsabm.2c00345⟩. ⟨hal-03851896⟩
43 Consultations
130 Téléchargements



Gmail Facebook X LinkedIn More