COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA) - Université de Montpellier
Article Dans Une Revue Journal of Hematology and Oncology Année : 2021

COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)

Livio Pagano (1, 2) , Jon Salmanton-García (3, 4) , Francesco Marchesi (5) , Alessandro Busca (6) , Paolo Corradini (7) , Martin Hoenigl (8, 9) , Nikolai Klimko (10) , Philipp Koehler (11) , Antonio Pagliuca (12) , Francesco Passamonti (13) , Luisa Verga (14) , Benjamin Víšek (15) , Osman Ilhan (16) , Gianpaolo Nadali (17) , Barbora Weinbergerová (18) , Raúl Córdoba-Mascuñano (19) , Monia Marchetti (20) , Graham Collins (21) , Francesca Farina (22) , Chiara Cattaneo (23) , Alba Cabirta (24, 25) , Maria Gomes-Silva (26) , Federico Itri (27) , Jaap van Doesum (28) , Marie-Pierre Ledoux (29) , Martin Čerňan (30) , Ozren Jakšić (31) , Rafael Duarte (32) , Gabriele Magliano (33) , Ali Omrani (34) , Nicola Fracchiolla (35) , Austin Kulasekararaj (12) , Toni Valković (36, 37) , Christian Bjørn Poulsen (38) , Marina Machado (39) , Andreas Glenthøj (40) , Igor Stoma (41) , Zdeněk Ráčil (42) , Klára Piukovics (43) , Milan Navrátil (44) , Ziad Emarah (45) , Uluhan Sili (46) , Johan Maertens (47) , Ola Blennow (48) , Rui Bergantim (49, 50, 51, 52) , Carolina García-Vidal (53) , Lucia Prezioso (35) , Anna Guidetti (7) , Maria Ilaria del Principe (54) , Marina Popova (55) , Nick de Jonge (56) , Irati Ormazabal-Vélez (57) , Noemí Fernández (58) , Iker Falces-Romero (59) , Annarosa Cuccaro (60) , Stef Meers (61) , Caterina Buquicchio , Darko Antić (62, 63) , Murtadha Al-Khabori (64) , Ramón García-Sanz (65, 66) , Monika Biernat (67) , Maria Chiara Tisi (68) , Ertan Sal (11) , Laman Rahimli (11) , Natasa Čolović (63) , Martin Schönlein (69) , Maria Calbacho (70) , Carlo Tascini (71) , Carolina Miranda-Castillo (72) , Nina Khanna (73) , Gustavo-Adolfo Méndez , Verena Petzer (74) , Caroline Besson (75) , Rémy Duléry (76) , Sylvain Lamure (77, 78) , Marcio Nucci (79) , Giovanni Zambrotta (80, 81) , Pavel Žák (15) , Guldane Cengiz Seval (16) , Valentina Bonuomo (17) , Jiří Mayer (18) , Alberto López-García (19) , Maria Vittoria Sacchi (20) , Stephen Booth (82) , Fabio Ciceri (83) , Margherita Oberti (23) , Marco Salvini (84) , Macarena Izuzquiza (24, 25) , Raquel Nunes-Rodrigues (26) , Emanuele Ammatuna (28) , Aleš Obr (85) , Raoul Herbrecht (29) , Lucía Núñez-Martín-Buitrago (32) , Valentina Mancini (86) , Hawraa Shwaylia (34) , Mariarita Sciumè (35) , Jenna Essame (12) , Marietta Nygaard (37) , Josip Batinić (37, 87) , Yung Gonzaga (88) , Isabel Regalado-Artamendi (39) , Linda Katharina Karlsson (89) , Maryia Shapetska (90) , Michaela Hanakova (42) , Shaimaa El-Ashwah (45) , Zita Borbényi (43) , Gökçe Melis Çolak (46) , Anna Nordlander (48) , Giulia Dragonetti (1, 2) , Alessio Maria Edoardo Maraglino (1, 2) , Amelia Rinaldi (35) , Cristina de Ramón-Sánchez (66) , Oliver Cornely (3, 4, 91) , Jan Novák
1 Fondazione Policlinico Universitario Agostino Gemelli IRCCS
2 Unicatt - Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
3 University Hospital of Cologne [Cologne]
4 Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)
5 IRE - IFO - Istituto Nazionale Tumori Regina Elena [Roma]
6 A.O.U - Città della Salute e della Scienza di Torino
7 IRCCS Istituto Nazionale dei Tumori [Milano]
8 UC San Diego - University of California [San Diego]
9 Medical University of Graz = Medizinische Universität Graz
10 Odessa National I.I.Mechnikov University
11 Faculty of Medicine [Cologne]
12 KCH - King's College Hospital
13 Uninsubria - Universitá degli Studi dell’Insubria = University of Insubria [Varese]
14 Dipartimento di Medicina e Chirurgia = School of Medicine and Surgery [Monza]
15 Faculty of Medicine in Hradec Kralove [Republique Tchèque]
16 Ankara University School of Medicine [Turkey]
17 Azienda Ospedaliera Universitaria Integrata of Verona
18 MUNI - Masaryk University [Brno]
19 FJD - Hospital Universitario Fundación Jiménez Díaz [Madrid]
20 Ospedale SS Antonio e Biagio e Cesare Arrigo
21 Churchill Hospital Oxford Centre for Haematology
22 IRCCS San Raffaele Scientific Institute [Milan, Italie]
23 ASST Spedali Civili of Brescia,
24 VHIO - Vall d'Hebron Institute of Oncology [Barcelone]
25 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
26 IPO Porto - Instituto Português de Oncologia do Porto / Portuguese Oncology Institute of Porto
27 Ospedale San Luigi Gonzaga
28 UMCG - University Medical Center Groningen [Groningen]
29 ICANS - Institut de Cancérologie de Strasbourg Europe
30 Palacky University Olomouc
31 Dubrava University Hospital - Zagreb School of Medicine [Zagreb, Croatia]
32 Hospital Universitario Puerta de Hierro-Majadahonda [Madrid, Spain]
33 ASST Great Metropolitan Niguarda / ASST Grande Ospedale Metropolitano Niguarda [Milan, Italia]
34 Hamad Medical Corporation [Doha, Qatar]
35 Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
36 University of Rijeka
37 CROHEM - Croatian Cooperative Group for Hematological Diseases
38 Zealand University Hospital [Roskilde, Denmark]
39 Hospital General Universitario "Gregorio Marañón" [Madrid]
40 Department of Clinical Microbiology [Rigshospitalet]
41 GSMU - Homieĺ State Medical University
42 Institute of Hematology and Blood Transfusion [Prague, Czech Republic]
43 University of Szeged [Szeged]
44 University Hospital Ostrava
45 Mansoura University [Egypt]
46 Marmara University [Kadıköy - İstanbul]
47 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
48 Karolinska University Hospital [Stockholm]
49 I3S - Instituto de Investigação e Inovação em Saúde
50 IPATIMUP - Instituto de Patologia e Imunologia Molecular da Universidade do Porto
51 Hospital de São João [Porto]
52 FMUP - Faculdade de Medicina da Universidade do Porto
53 Clinic Barcelona Hospital Universitari
54 Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]
55 Pavlov First Saint Petersburg State Medical University [St. Petersburg]
56 VUMC - Vrije Universiteit Medical Centre
57 Complejo Hospitalario de Navarra
58 Hospital Universitario Marqués de Valdecilla [Santander]
59 La Paz University Hospital
60 Azienda Usl Toscana centro [Firenze]
61 AZ Klina
62 KCS - Clinical Center of Serbia
63 University of Belgrade [Belgrade]
64 SQU - Sultan Qaboos University
65 Hospital Clinico Universitario de Salamanca [España] = University Hospital of Salamanca [Spain]
66 Centro de Investigación del Cáncer-IBMCC (USAL-CSIC)
67 UWr - University of Wrocław [Poland]
68 San Bortolo Hospital
69 UKE - Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg]
70 Hospital Universitario 12 de Octubre [Madrid]
71 ASU FC - Azienda Sanitaria Universitaria Friuli Centrale
72 URJC - Universidad Rey Juan Carlos = Rey Juan Carlos University
73 Unibas - Université de Bâle = University of Basel = Basel Universität
74 IMU - Innsbruck Medical University = Medizinische Universität Innsbruck
75 CHV - Centre Hospitalier de Versailles André Mignot
76 CRSA - Centre de Recherche Saint-Antoine
77 IGMM - Institut de Génétique Moléculaire de Montpellier
78 Département Hématologie biologique [CHRU Montpellier]
79 UNIRIO - Universidade Federal do Estado do Rio de Janeiro
80 San Gerardo Hospital of Monza
81 UNIMIB - Università degli Studi di Milano-Bicocca = University of Milano-Bicocca
82 Oxford NIHR Biomedical Research Centre
83 IRCCS Ospedale San Raffaele [Milan, Italy]
84 Assi Sette Llaghi Varese
85 University Hospital Olomouc [Czech Republic]
86 ASST Grande Ospedale Metropolitano Niguarda
87 University Hospital Centre Zagreb
88 Instituto Nacional do Câncer
89 Rigshospitalet [Copenhagen]
90 Republican Scientific and Practical Center (RSPC) for organ and Tissue Transplantation, Minsk
91 DZIF - German Centre for Infection Research
Livio Pagano
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
Jon Salmanton-García
University Hospital of Cologne [Cologne]
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)
Francesco Marchesi
IFO - Istituto Nazionale Tumori Regina Elena [Roma]
Alessandro Busca
Città della Salute e della Scienza di Torino
Paolo Corradini
IRCCS Istituto Nazionale dei Tumori [Milano]
Martin Hoenigl
University of California [San Diego]
Medical University of Graz = Medizinische Universität Graz
Nikolai Klimko
Odessa National I.I.Mechnikov University
Philipp Koehler
Faculty of Medicine [Cologne]
Antonio Pagliuca
King's College Hospital
Francesco Passamonti
Universitá degli Studi dell’Insubria = University of Insubria [Varese]
Luisa Verga
Dipartimento di Medicina e Chirurgia = School of Medicine and Surgery [Monza]
Benjamin Víšek
Faculty of Medicine in Hradec Kralove [Republique Tchèque]
Osman Ilhan
Ankara University School of Medicine [Turkey]
Gianpaolo Nadali
Azienda Ospedaliera Universitaria Integrata of Verona
Barbora Weinbergerová
Masaryk University [Brno]
Raúl Córdoba-Mascuñano
Hospital Universitario Fundación Jiménez Díaz [Madrid]
Monia Marchetti
Ospedale SS Antonio e Biagio e Cesare Arrigo
Graham Collins
Churchill Hospital Oxford Centre for Haematology
Francesca Farina
IRCCS San Raffaele Scientific Institute [Milan, Italie]
Chiara Cattaneo
ASST Spedali Civili of Brescia,
Alba Cabirta
Vall d'Hebron Institute of Oncology [Barcelone]
Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
Maria Gomes-Silva
Instituto Português de Oncologia do Porto / Portuguese Oncology Institute of Porto
Federico Itri
Ospedale San Luigi Gonzaga
Jaap van Doesum
University Medical Center Groningen [Groningen]
Marie-Pierre Ledoux
Institut de Cancérologie de Strasbourg Europe
Martin Čerňan
Palacky University Olomouc
Ozren Jakšić
Zagreb School of Medicine [Zagreb, Croatia]
Rafael Duarte
Hospital Universitario Puerta de Hierro-Majadahonda [Madrid, Spain]
Gabriele Magliano
ASST Great Metropolitan Niguarda / ASST Grande Ospedale Metropolitano Niguarda [Milan, Italia]
Ali Omrani
Hamad Medical Corporation [Doha, Qatar]
Nicola Fracchiolla
Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
Austin Kulasekararaj
King's College Hospital
Toni Valković
University of Rijeka
Croatian Cooperative Group for Hematological Diseases
Christian Bjørn Poulsen
Zealand University Hospital [Roskilde, Denmark]
Marina Machado
Hospital General Universitario "Gregorio Marañón" [Madrid]
Andreas Glenthøj
Department of Clinical Microbiology [Rigshospitalet]
Igor Stoma
Homieĺ State Medical University
Zdeněk Ráčil
Institute of Hematology and Blood Transfusion [Prague, Czech Republic]
Klára Piukovics
University of Szeged [Szeged]
Milan Navrátil
University Hospital Ostrava
Ziad Emarah
Mansoura University [Egypt]
Uluhan Sili
Marmara University [Kadıköy - İstanbul]
Johan Maertens
Catholic University of Leuven = Katholieke Universiteit Leuven
Ola Blennow
Karolinska University Hospital [Stockholm]
Rui Bergantim
Instituto de Investigação e Inovação em Saúde
Instituto de Patologia e Imunologia Molecular da Universidade do Porto
Hospital de São João [Porto]
Faculdade de Medicina da Universidade do Porto
Carolina García-Vidal
Clinic Barcelona Hospital Universitari
Lucia Prezioso
Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
Anna Guidetti
IRCCS Istituto Nazionale dei Tumori [Milano]
Maria Ilaria del Principe
Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]
Marina Popova
Pavlov First Saint Petersburg State Medical University [St. Petersburg]
Nick de Jonge
Vrije Universiteit Medical Centre
Irati Ormazabal-Vélez
Complejo Hospitalario de Navarra
Noemí Fernández
Hospital Universitario Marqués de Valdecilla [Santander]
Iker Falces-Romero
La Paz University Hospital
Annarosa Cuccaro
Azienda Usl Toscana centro [Firenze]
Stef Meers
AZ Klina
Caterina Buquicchio
Darko Antić
Clinical Center of Serbia
University of Belgrade [Belgrade]
Murtadha Al-Khabori
Sultan Qaboos University
Ramón García-Sanz
Hospital Clinico Universitario de Salamanca [España] = University Hospital of Salamanca [Spain]
Centro de Investigación del Cáncer-IBMCC (USAL-CSIC)
Monika Biernat
University of Wrocław [Poland]
Maria Chiara Tisi
San Bortolo Hospital
Ertan Sal
Faculty of Medicine [Cologne]
Laman Rahimli
Faculty of Medicine [Cologne]
Natasa Čolović
University of Belgrade [Belgrade]
Martin Schönlein
Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg]
Maria Calbacho
Hospital Universitario 12 de Octubre [Madrid]
Carlo Tascini
Azienda Sanitaria Universitaria Friuli Centrale
Carolina Miranda-Castillo
Universidad Rey Juan Carlos = Rey Juan Carlos University
Nina Khanna
Université de Bâle = University of Basel = Basel Universität
Gustavo-Adolfo Méndez
Verena Petzer
Innsbruck Medical University = Medizinische Universität Innsbruck
Caroline Besson
Centre Hospitalier de Versailles André Mignot
Rémy Duléry
Centre de Recherche Saint-Antoine
Sylvain Lamure
Institut de Génétique Moléculaire de Montpellier
Département Hématologie biologique [CHRU Montpellier]
CV
Marcio Nucci
Universidade Federal do Estado do Rio de Janeiro
Giovanni Zambrotta
San Gerardo Hospital of Monza
Università degli Studi di Milano-Bicocca = University of Milano-Bicocca
Pavel Žák
Faculty of Medicine in Hradec Kralove [Republique Tchèque]
Guldane Cengiz Seval
Ankara University School of Medicine [Turkey]
Valentina Bonuomo
Azienda Ospedaliera Universitaria Integrata of Verona
Jiří Mayer
Masaryk University [Brno]
Alberto López-García
Hospital Universitario Fundación Jiménez Díaz [Madrid]
Maria Vittoria Sacchi
Ospedale SS Antonio e Biagio e Cesare Arrigo
Stephen Booth
Oxford NIHR Biomedical Research Centre
Fabio Ciceri
IRCCS Ospedale San Raffaele [Milan, Italy]
Margherita Oberti
ASST Spedali Civili of Brescia,
Marco Salvini
  • Fonction : Auteur
Assi Sette Llaghi Varese
Macarena Izuzquiza
  • Fonction : Auteur
Vall d'Hebron Institute of Oncology [Barcelone]
Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
Raquel Nunes-Rodrigues
Instituto Português de Oncologia do Porto / Portuguese Oncology Institute of Porto
Emanuele Ammatuna
University Medical Center Groningen [Groningen]
Aleš Obr
University Hospital Olomouc [Czech Republic]
Raoul Herbrecht
Institut de Cancérologie de Strasbourg Europe
Lucía Núñez-Martín-Buitrago
Hospital Universitario Puerta de Hierro-Majadahonda [Madrid, Spain]
Valentina Mancini
  • Fonction : Auteur
ASST Grande Ospedale Metropolitano Niguarda
Hawraa Shwaylia
Hamad Medical Corporation [Doha, Qatar]
Mariarita Sciumè
Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
Jenna Essame
King's College Hospital
Marietta Nygaard
Croatian Cooperative Group for Hematological Diseases
Josip Batinić
Croatian Cooperative Group for Hematological Diseases
University Hospital Centre Zagreb
Yung Gonzaga
Instituto Nacional do Câncer
Isabel Regalado-Artamendi
Hospital General Universitario "Gregorio Marañón" [Madrid]
Linda Katharina Karlsson
Rigshospitalet [Copenhagen]
Maryia Shapetska
Republican Scientific and Practical Center (RSPC) for organ and Tissue Transplantation, Minsk
Michaela Hanakova
Institute of Hematology and Blood Transfusion [Prague, Czech Republic]
Shaimaa El-Ashwah
Mansoura University [Egypt]
Zita Borbényi
University of Szeged [Szeged]
Gökçe Melis Çolak
Marmara University [Kadıköy - İstanbul]
Anna Nordlander
Karolinska University Hospital [Stockholm]
Giulia Dragonetti
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
Alessio Maria Edoardo Maraglino
  • Fonction : Auteur
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
Amelia Rinaldi
Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
Cristina de Ramón-Sánchez
Centro de Investigación del Cáncer-IBMCC (USAL-CSIC)
Oliver Cornely
University Hospital of Cologne [Cologne]
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)
German Centre for Infection Research
Jan Novák

Résumé

Background Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality. Methods The survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020. Results The study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients ( n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March–May 2020) and the second wave (October–December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases. Conclusions This survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases.

Domaines

Maladies infectieuses Cancer Hématologie Santé publique et épidémiologie
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hal-03642030 , version 1 (26-04-2022)

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Livio Pagano, Jon Salmanton-García, Francesco Marchesi, Alessandro Busca, Paolo Corradini, et al.. COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA). Journal of Hematology and Oncology, 2021, 14 (1), pp.168. ⟨10.1186/s13045-021-01177-0⟩. ⟨hal-03642030⟩

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