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Article Dans Une Revue Kidney International Reports Année : 2021

Renal Prognosis in Children With Tubulointerstitial Nephritis and Uveitis Syndrome

Françoise Broux
  • Fonction : Auteur
Corentin Tanne
Lise Allard
  • Fonction : Auteur
Tim Ulinski
  • Fonction : Auteur


Introduction: Tubulointerstitial nephritis (TIN) and uveitis (TINU) syndrome is a rare disease. The renal prognosis is generally thought to be better in children with TINU syndrome than in adults. However, data are scarce. We aimed to investigate the long-term renal prognosis in a French cohort of children with TINU syndrome. Methods: We performed a national retrospective study including 23 French pediatric nephrology centers enrolling patients with TINU syndrome diagnosed between January 2000 and December 2018. Results: A total of 46 patients were included (52% female, median age 13.8 years). At diagnosis of TIN, the median estimated glomerular filtration rate (eGFR) was 30.6 ml/min per 1.73 m2 (4.9-62.8). The median time between diagnosis of uveitis and TIN was 0.4 months (-4.1; +17.1). All patients had anterior uveitis, but 12 (29%) were asymptomatic. Nearly all patients (44 of 46) received steroid treatment, and 12 patients (26%) received a second-line therapy. At last follow-up (median 2.8 years), the median eGFR was 87.5 ml/min per 1.73 m2 (60.3-152.7) and <90 ml/min per 1.73 m2 in 20 patients. Conclusion: In our study, nearly half of the patients had renal sequelae at last follow-up. Given the possible progression to chronic kidney disease, long-term monitoring of children with TINU syndrome is mandatory. Approximately a quarter of the children had asymptomatic uveitis suggesting all children presenting with TIN should undergo systematic ophthalmologic screening even in the absence of ocular signs.
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Dates et versions

hal-03636866 , version 1 (11-04-2022)




Agnès Chevalier, Claire Duflos, Stephanie Clave, Olivia Boyer, Julien Hogan, et al.. Renal Prognosis in Children With Tubulointerstitial Nephritis and Uveitis Syndrome. Kidney International Reports, 2021, 6 (12), pp.3045-3053. ⟨10.1016/j.ekir.2021.09.017⟩. ⟨hal-03636866⟩
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