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Article Dans Une Revue Radiotherapy & Oncology Année : 2015

New ways to image and target tumour hypoxia and its molecular responses

Résumé

Tumour hypoxia and its molecular responses have been shown to be associated with poor prognosis. Detection of hypoxia, preferably in a non-invasive manner, could therefore predict treatment outcome and serve as a tool to individualize treatment. This review gives an overview of recent literature on hypoxia imaging markers currently used in clinical trials. Furthermore, recent progress made in targeting hypoxia (hypoxia-activated prodrugs) or hypoxia response (carbonic anhydrase IX inhibitors) is summarized. Last, window-of-opportunity trials implementing non-invasive imaging are proposed as an important tool to prove anti-tumour efficacy of experimental drugs early during drug development.

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Cancer Imagerie
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Origine : Publication financée par une institution

Dates et versions

hal-03621578 , version 1 (28-03-2022)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Ludwig Dubois, Raymon Niemans, Simon J.A. van Kuijk, Kranthi Panth, Nanda-Kumar Parvathaneni, et al.. New ways to image and target tumour hypoxia and its molecular responses. Radiotherapy & Oncology, 2015, 116 (3), pp.352 - 357. ⟨10.1016/j.radonc.2015.08.022⟩. ⟨hal-03621578⟩
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