Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosonium tetrafluoroborate: Towards new carbonic anhydrase glycoinhibitors - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Bioorganic and Medicinal Chemistry Année : 2014

Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosonium tetrafluoroborate: Towards new carbonic anhydrase glycoinhibitors

Résumé

Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosonium tetrafluoroborate allowed the preparation of hydroxysulfamide glycosides in good yields with a good α stereoselectivity. A variety of mono-saccharide derivatives was synthesized using this new methodology leading to selective and powerful glycoinhibitors of the tumor associated carbonic anhydrases (CA, EC 4.2.1.1) isoforms CA IX and CA XII.

Dates et versions

hal-03619392 , version 1 (25-03-2022)

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Citer

Joanna Ombouma, Daniela Vullo, Claudiu Supuran, Jean-Yves Winum. Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosonium tetrafluoroborate: Towards new carbonic anhydrase glycoinhibitors. Bioorganic and Medicinal Chemistry, 2014, 22 (22), pp.6353-6359. ⟨10.1016/j.bmc.2014.09.053⟩. ⟨hal-03619392⟩
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