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Article Dans Une Revue Journal of Enzyme Inhibition and Medicinal Chemistry Année : 2014

Metal-based carboxamide-derived compounds endowed with antibacterial and antifungal activity

Résumé

A series of three bioactive thiourea (carboxamide) derivatives, N-(dipropylcarbamothioyl)-thiophene-2-carboxamide (L(1)), N-(dipropylcarbamothioyl)-5-methylthiophene-2-carboxamide (L(2)) and 5-bromo-N-(dipropylcarbamothioyl)furan-2-carboxamide (L(3)) and their cobalt(II), copper(II), nickel(II) and zinc(II) complexes (1)-(12) have been synthesized and characterized by their IR,(1)H-NMR spectroscopy, mass spectrometry and elemental analysis data. The Crystal structure of one of the ligand, N-(dipropylcarbamothioyl)thiophene-2-carboxamide (L(1)) and its nickel(II) and copper(II) complexes were determined from single crystal X-ray diffraction data. All the ligands and metal(II) complexes have been subjected to in vitro antibacterial and antifungal activity against six bacterial species (Escherichia coli. Shigella flexneri. Pseudomonas aeruginosa. Salmonella typhi. Staphylococcus aureus and Bacillus subtilis) and for antifungal activity against six fungal strains (Trichophyton longifusus. Candida albicans. Aspergillus flavus. Microsporum canis. Fusarium solani and Candida glabrata). The in vitro antibacterial and antifungal bioactivity data showed the metal(II) complexes to be more potent than the parent ligands against one or more bacterial and fungal strains.

Domaines

Chimie
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Dates et versions

hal-03619357 , version 1 (25-03-2022)

Identifiants

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Muhammad Hanif, Zahid Chohan, Jean-Yves Winum, Javeed Akhtar. Metal-based carboxamide-derived compounds endowed with antibacterial and antifungal activity. Journal of Enzyme Inhibition and Medicinal Chemistry, 2014, 29 (4), pp.517-526. ⟨10.3109/14756366.2013.815178⟩. ⟨hal-03619357⟩
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