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Article Dans Une Revue Tetrahedron Letters Année : 2013

Synthesis of rapamycin glycoconjugates via a CuAAC-based approach

Résumé

The conversion of the C40 secondary hydroxyl group of rapamycin into the azido group was followed by copper catalyzed cycloaddition of the resulting azido-rapamcin with various unprotected propargyl O- and S-glycosides and a C-ethynyl derivative. This approach furnished a collection of triazole-bridged rapamycin glycoconjugates (14 examples) in 44–83% isolated yield.

Domaines

Chimie
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Dates et versions

hal-03617716 , version 1 (23-03-2022)

Identifiants

Citer

Lisa Moni, Alberto Marra, Jerauld Skotnicki, Frank Koehn, Magid Abou-Gharbia, et al.. Synthesis of rapamycin glycoconjugates via a CuAAC-based approach. Tetrahedron Letters, 2013, 54 (51), pp.6999-7003. ⟨10.1016/j.tetlet.2013.10.026⟩. ⟨hal-03617716⟩
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