Synthesis of mesoporous silica nanoparticles and nanorods: Application to doxorubicin delivery - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Solid State Sciences Année : 2017

Synthesis of mesoporous silica nanoparticles and nanorods: Application to doxorubicin delivery

Résumé

The synthesis and application of mesoporous silica nanoparticles (MSN) and mesoporous silica nanorods (MSNR) for drug delivery were described. MSN or MSNR were obtained by adjusting the amount of added cosolvent to the sol-gel solution. Therefore, the addition of ethanol (EtOH) has contributed to the control of the particle shape and to the structure of the mesoporosity. MSN and MSNR particles were then loaded with doxorubicin and incubated with MCF-7 breast cancer cells. MSN and MSNR particles were efficient in killing cancer cells but their behavior in drug delivery was altered on account of the difference in their morphology. MSN showed a burst release of doxorubicin in cells whereas MSNR showed a sustained delivery of the anti-cancer drug.

Domaines

Chimie
Fichier non déposé

Dates et versions

hal-03577141 , version 1 (16-02-2022)

Identifiants

Citer

Saher Rahmani, Jean-Olivier Durand, Clarence Charnay, Laure Lichon, Mokhtar Férid, et al.. Synthesis of mesoporous silica nanoparticles and nanorods: Application to doxorubicin delivery. Solid State Sciences, 2017, 68, pp.25-31. ⟨10.1016/j.solidstatesciences.2017.04.003⟩. ⟨hal-03577141⟩
17 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More