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Article Dans Une Revue Bioorganic & Medicinal Chemistry Letters Année : 2013

Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives

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Résumé

Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans species.

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Chimie
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Dates et versions

hal-03563007 , version 1 (09-02-2022)

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Ludovic Maillard, Sébastien Bertout, Ophélie Quinonéro, Gülşen Akalin, Gülhan Turan-Zitouni, et al.. Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives. Bioorganic & Medicinal Chemistry Letters, 2013, 23 (6), pp.1803-1807. ⟨10.1016/j.bmcl.2013.01.039⟩. ⟨hal-03563007⟩
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