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Article Dans Une Revue Tetrahedron Letters Année : 2013

An efficient synthesis of pyrido-imidazodiazepinediones

Résumé

We herein report the synthesis of a series of 12 optically pure 3,4-dihydro-1H-pyrido-[1′,2′:1,2]-imidazo[4,5-d][1,3]diazepine-2,5-diones, which form a new family of azaheterocycle-fused [1,3]diazepines. The key step of the synthesis consists in a selective C-acylation of 2-amino-imidazo[1,2-a]pyridine by various natural amino-acids, followed by an intracarbonylation reaction.

Domaines

Chimie
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Dates et versions

hal-03562647 , version 1 (09-02-2022)

Identifiants

Citer

Dominique Arama, Vincent Lisowski, Eliana Scarlata, Pierre Fulcrand, Ludovic Maillard, et al.. An efficient synthesis of pyrido-imidazodiazepinediones. Tetrahedron Letters, 2013, 54 (11), pp.1364-1367. ⟨10.1016/j.tetlet.2012.12.087⟩. ⟨hal-03562647⟩
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