Growth, clinical and neurodevelopmental outcomes at school age are similar for children who received 1-year lamivudine or lopinavir/ritonavir HIV prophylaxis in early life - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Scientific Reports Année : 2021

Growth, clinical and neurodevelopmental outcomes at school age are similar for children who received 1-year lamivudine or lopinavir/ritonavir HIV prophylaxis in early life

Mandisa Singata-Madliki
  • Fonction : Auteur
Joyce Nalugya
  • Fonction : Auteur
Melany Tonga
  • Fonction : Auteur
James Tumwine
  • Fonction : Auteur
Nicolas Meda
Chipepo Kankasa
  • Fonction : Auteur
Mwiya Mwiya
  • Fonction : Auteur
Paul Bangirana
  • Fonction : Auteur
Joanne Batting
  • Fonction : Auteur
Grace Ndeezi
  • Fonction : Auteur

Résumé

Abstract In the ANRS 12174 trial, HIV-exposed uninfected African neonates who received lopinavir-ritonavir (LPV/r) prophylaxis for 1 year exhibited slower growth from birth to week 50 compared with those receiving lamivudine (3TC). We assessed whether this difference in growth persisted over time, and was accompanied by differences in neuropsychological and clinical outcomes. Between February 2017 and February 2018, we conducted a cross-sectional clinical evaluation among former trial participants who completed the 50-week follow-up and who were not HIV-infected. In addition to clinical examination, neuropsychological outcomes were assessed using the tests Kaufman-ABCII, Test of Variables of Attention, Movement Assessment Battery for Children and the Strengths and Difficulties questionnaire, parent version. Of 1101 eligible children, aged 5–7 years, 553 could be traced and analysed (274 in the LPV/r and 279 in the 3TC groups). Growth, clinical and neuropsychological outcomes did not differ between treatment groups. At school age, children exposed to LPV/r and 3TC at birth for 1 year had comparable growth and neuropsychological outcomes without evidence of long-term side-effects of LPV/r. It provides reassuring data on clinical outcomes for all HIV-infected children treated with this antiretroviral drug in early life.
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hal-03561358 , version 1 (02-05-2022)

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Nicolas Nagot, Mandisa Singata-Madliki, Amandine Cournil, Joyce Nalugya, Souleymane Tassembedo, et al.. Growth, clinical and neurodevelopmental outcomes at school age are similar for children who received 1-year lamivudine or lopinavir/ritonavir HIV prophylaxis in early life. Scientific Reports, 2021, 11 (1), pp.3173. ⟨10.1038/s41598-021-82762-8⟩. ⟨hal-03561358⟩
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