Ten‐year outcomes of anti‐vascular endothelial growth factor treatment for neovascular age‐related macular disease: A single‐centre French study - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Journal of Clinical & Experimental Ophthalmology Année : 2020

Ten‐year outcomes of anti‐vascular endothelial growth factor treatment for neovascular age‐related macular disease: A single‐centre French study

Résumé

Long-term data of intravitreal injections of vascular endothelial growth factor (VEGF) inhibitors are lacking. Background: This study aims to assess visual and anatomic outcomes of eyes with neovascular age-related macular degeneration (nAMD) after 10 years of anti-VEGF therapy. Design: Retrospective analysis of data from a prospectively designed database. Participants: One hundred and sixteen eyes with nAMD (94 participants) that started anti-VEGF therapy at least 10 years earlier. Methods: Eyes were tracked by the Fight Retinal Blindness! registry. Main outcome measures: Mean change in visual acuity at 10 years vs baseline. Visual acuity was assessed by the number of letters read on a logarithm of the minimum angle of resolution chart. Results: Eyes received a median of 27.5 injections over 10 years. Mean visual acuity was 57.5 letters (SD 17.5) at baseline. It increased slightly at 1 year, then dropped steadily by 18 letters (95% CI: 13.7; 22.3) at 10 years. Overall, 10% of eyes gained ≥10 letters, 64% lost ≥10 letters and 23% remained stable (±5 letters from baseline). Geographic atrophy and subretinal fibrosis were found in 93% and 71%, respectively, after 10 years, both mostly affecting the centre of the fovea. Pre-treated eyes (47.5%) had significantly worse visual acuity than treatment-naïve eyes at baseline and during follow-up and were significantly more likely to have atrophy and fibrosis. Conclusions and relevance: Despite short-term stabilization, long-term visual outcomes of nAMD eyes under anti-VEGF therapy may be poor. Development of atrophy and fibrosis, resulting from the natural progression of the disease, may partly explain this evolution.
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Dates et versions

hal-03537231 , version 1 (20-01-2022)

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Benjamin Wolff, Valerie Macioce, Vivien Vasseur, Laurent Castelnovo, Guillaume Michel, et al.. Ten‐year outcomes of anti‐vascular endothelial growth factor treatment for neovascular age‐related macular disease: A single‐centre French study. Journal of Clinical & Experimental Ophthalmology, 2020, 48 (5), pp.636-643. ⟨10.1111/ceo.13742⟩. ⟨hal-03537231⟩
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