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Article Dans Une Revue Angewandte Chemie International Edition Année : 2012

Combination of Phage Display and Molecular Grafting Generates Highly Specific Tumor-Targeting Miniproteins

Résumé

Frankenstein's peptide: the grafting of the binding domain from miniprotein Min-23 into the sunflower trypsin inhibitor (SFTI-I) peptide scaffold preserved its in vitro and in vivo binding specificity and proteolytic stability. The combination of these peptides was shown to be tumor-specific with a good binding affinity for delta-like ligand 4 (Dll4) protein. The use of SFTI-I as a peptide scaffold is ideal for hit-to-lead development.

Dates et versions

hal-03472310 , version 1 (09-12-2021)

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Citer

Frederic Zoller, Annette Markert, Philippe Barthe, Wenye Zhao, Wilko Weichert, et al.. Combination of Phage Display and Molecular Grafting Generates Highly Specific Tumor-Targeting Miniproteins. Angewandte Chemie International Edition, 2012, 51 (52), pp.13136-13139. ⟨10.1002/anie.201203857⟩. ⟨hal-03472310⟩
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