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In vivo exposure of marine mussels to venlafaxine: bioconcentration and metabolization

Abstract : Pharmaceuticals are present in natural waters, thus contributing to the general exposure of aquatic organisms, but few data are available on the accumulation of these substances in marine organisms. The present study evaluated the in vivo bioconcentration of an antidepressant-venlafaxine (VLF)-in marine mussels (Mytilus galloprovincialis) during 7 days of exposure at nominal 10 mu g/L concentration, followed by a 7-day depuration period. The bioconcentration factor (BCF) was 265 mL/g dry weight (dw). VLF accumulation reached an average tissue concentration of 2146 +/- 156 ng/g dw within 7 days, showing a first-order kinetics process. N-desmethylvenlafaxine (N-VLF) and O-desmethylvenlafaxine (O-VLF) metabolites were quantified in mussel tissues, whereas N,N-didesmethylvenlafaxine (NN-VLF) was only recorded as being detected. These three metabolites were also quantified in water, indicating an active metabolism and VLF excretion in Mediterranean mussels. Complementary experiments conducted at nominal concentrations of 1, 10, and 100 mu g/L for 7 days confirmed the VLF bioconcentration and metabolism and allowed us to quantify a supplementary metabolite, i.e., N,O-didesmethylvenlafaxine (NO-VLF), in mussel tissues. These results encourage further research on a more complete characterization of metabolism and on any disturbances linked to bioconcentration of VLF on bivalves.
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https://hal.umontpellier.fr/hal-03413536
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Soumis le : mercredi 3 novembre 2021 - 19:02:45
Dernière modification le : mardi 17 mai 2022 - 13:40:04

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Elena Gomez, Clothilde Boillot, Maria Jesus Martinez Bueno, Dominique Munaron, Olivier Mathieu, et al.. In vivo exposure of marine mussels to venlafaxine: bioconcentration and metabolization. Environmental Science and Pollution Research, Springer Verlag, 2021, ⟨10.1007/s11356-021-14893-4⟩. ⟨hal-03413536⟩

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