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Article Dans Une Revue Organic Letters Année : 2021

Dynamic Kinetic Resolution Processes Based on the Switchable Configurational Instability of Allenyl Copper Reagents

Nacira Alouane
  • Fonction : Auteur
Pierre Mangeney
  • Fonction : Auteur
Arie van Der Lee
Hélène Gerard

Résumé

The configurational instability of allenyl copper reagents is unveiled. An experimental study highlights the crucial role of Li+ and of the reaction temperature in the control of the configurational stability of allenyl copper reagents. A judicious choice of the reaction conditions allows efficient dynamic kinetic resolution processes and gives a one-pot access to homopropargylic alcohols or amines bearing up to four contiguous defined stereogenic centers.

Domaines

Chimie
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Dates et versions

hal-03348774 , version 1 (20-09-2021)

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Citer

Chayma Ben Maamer, Pierre Mpawenayo, Baptiste Lecachey, Nacira Alouane, Pierre Mangeney, et al.. Dynamic Kinetic Resolution Processes Based on the Switchable Configurational Instability of Allenyl Copper Reagents. Organic Letters, 2021, 23 (16), pp.6305-6310. ⟨10.1021/acs.orglett.1c02095⟩. ⟨hal-03348774⟩
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