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Article Dans Une Revue TH Open : Companion Journal To Thrombosis and Haemostasis Année : 2020

Flare of Antiphospholipid Syndrome in the Course of COVID-19

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We report the case of a 48-year-old man followed since 2013 for primary antiphospholipid syndrome (APLS) revealed by venous thromboembolism in the presence of antiphospholipid antibodies (APL-Abs, anticardiolipin and anti-β-2-glycoprotein-1), who decompensated in the course of coronavirus disease (COVID-19). Despite efficient anticoagulation, he suffered bilateral adrenal glands hemorrhage and limb arterial ischemia. The tropism of severe acute respiratory syndrome coronavirus-2 for endothelium can lead to microangiopathy and increased risk for thrombosis. If APL-Abs positivity can be an epiphenomenon under inflammatory and prothrombotic conditions, COVID-19 was herein responsible for disseminated thrombosis and a threat of catastrophic APLS, despite efficient anticoagulation.
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hal-03339015 , version 1 (09-09-2021)

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Alexandre Thibault Jacques Maria, Isabelle Diaz-Cau, Jean-Marc Benejean, Anaïs Nutz, Aurélie Schiffmann, et al.. Flare of Antiphospholipid Syndrome in the Course of COVID-19. TH Open : Companion Journal To Thrombosis and Haemostasis, 2020, 04 (03), pp.e207-e210. ⟨10.1055/s-0040-1716735⟩. ⟨hal-03339015⟩
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