Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Neurobiology of Aging Année : 2021

Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease

Nicolas Dupré

Résumé

Rare mutations in genes originally discovered in multigenerational families have been associated with increased risk of Parkinson's disease (PD). The involvement of rare variants in DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 loci has been poorly studied or has produced conflicting results across cohorts. However, they are still being often referred to as "PD genes" and used in different models. To further elucidate the role of these 5 genes in PD, we fully sequenced them using molecular inversion probes in 2408 patients with PD and 3444 controls from 3 different cohorts. A total of 788 rare variants were identified across the 5 genes and 3 cohorts. Burden analyses and optimized sequence Kernel association tests revealed no significant association between any of the genes and PD after correction for multiple comparisons. Our results do not support an association of the 5 tested genes with PD. Combined with previous studies, it is unlikely that any of these genes plays an important role in PD. Their designation as "PARK" genes should be reconsidered.
Fichier principal
Vignette du fichier
nihms-1642560.pdf (123.94 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03226126 , version 1 (25-04-2022)

Identifiants

Citer

Prabhjyot Saini, Uladzislau Rudakou, Eric Yu, Jennifer Ruskey, Farnaz Asayesh, et al.. Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease. Neurobiology of Aging, 2021, 100, pp.119.e7-119.e13. ⟨10.1016/j.neurobiolaging.2020.10.019⟩. ⟨hal-03226126⟩
59 Consultations
68 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More