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Article Dans Une Revue Biochemical Society Transactions Année : 2007

A non-covalent peptide-based strategy for siRNA delivery

Résumé

The major obstacle to clinical development of siRNAs (short interfering RNAs), like for most of the nucleic-acid-based strategies, is their poor cellular uptake and bioavailability. Although several viral and non-viral strategies have been proposed to improve siRNA delivery, their applications in vivo remain a major challenge. We have developed a new strategy, based on a short amphipathic peptide, MPG, that is able to form stable nanoparticles with siRNA. MPG-based particles enter the cell independently of the endosomal pathway and can efficiently deliver siRNA in a fully biologically active form into a variety of cell lines and in vivo. This short review will discuss the mechanism and the potency of the MPG strategy for siRNA delivery both in vitro and in vivo.
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Dates et versions

hal-03176749 , version 1 (22-03-2021)

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Laurence Crombez, Annie Charnet, May C Morris, Gudrun Aldrian Herrada, Frédéric Heitz, et al.. A non-covalent peptide-based strategy for siRNA delivery. Biochemical Society Transactions, 2007, 35 (1), pp.44-46. ⟨10.1042/BST0350044⟩. ⟨hal-03176749⟩
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