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Article Dans Une Revue ACS Omega Année : 2020

Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy

Résumé

The mechanochemical preparation of silver sulfadiazine and dantrolene, two marketed active pharmaceutical ingredients, was investigated by in situ Raman spectroscopy. For the first time, the mechanochemical transformations involving highly fluorescent compounds could be studied in situ with a high-resolution Raman system combined with a unique suitable Raman probe. Moreover, the kinetic features of the mechanochemical process were examined by a mathematical model allowing to describe the chemical changes under mechanical stress. This approach is promising both to broaden the scope of Raman in situ investigations that would otherwise be impossible and for process optimization at any scale.

Domaines

Chimie
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Dates et versions

hal-03134457 , version 1 (25-05-2021)

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Irena Sović, Stipe Lukin, Ernest Meštrović, Ivan Halasz, Andrea Porcheddu, et al.. Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy. ACS Omega, 2020, 5 (44), pp.28663-28672. ⟨10.1021/acsomega.0c03756⟩. ⟨hal-03134457⟩
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