Effets de la réduction artificielle du blastocèle avant vitrification en système fermé : étude contrôlée randomisée - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Gynécologie Obstétrique & Fertilité Année : 2014

[Effects of artificial shrinkage prior to vitrification in a closed system: a randomized controlled trial].

Effets de la réduction artificielle du blastocèle avant vitrification en système fermé : étude contrôlée randomisée

Résumé

Objective: To evaluate the effect of induced blastocoele shrinkage before vitrification in a closed carrier device. Patients and methods: Prior to vitrification, blastocyst cavity was artificially shrinked by laser pulse or not treated according to a 2:1 randomized procedure. A total of 185 warming cycles from April 2011 to March 2013 have been analyzed. Clinical pregnancy rate and survival rate were compared between the two groups. The mean (±SD) women age was 33.5±5.7 years for both groups. Results: The pregnancy rate in the group with artificial reduction of the cavity was higher ([32/67] 47.7%) than in the control group but not significantly ([43/113] 38%). The survival rate in the artificial shrinkage group was significantly higher compared with the control group : 99% (102/103) and 91.8% (168/183) respectively (P=0.01). Discussion and conclusion: This study reveals that artificial shrinkage of blastocoelic cavity by laser pulse before vitrification in a closed carrier device improves survival rate after warming.
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Dates et versions

hal-03123192 , version 1 (27-01-2021)

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Citer

A. Gala, A. Ferrières, S. Assou, M. Monforte, S. Bringer-Deutsch, et al.. Effets de la réduction artificielle du blastocèle avant vitrification en système fermé : étude contrôlée randomisée. Gynécologie Obstétrique & Fertilité, 2014, 42 (11), pp.772-778. ⟨10.1016/j.gyobfe.2014.09.006⟩. ⟨hal-03123192⟩
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