Vegetable oil-based hybrid microparticles as a green and biocompatible system for subcutaneous drug delivery - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue International Journal of Pharmaceutics Année : 2021

Vegetable oil-based hybrid microparticles as a green and biocompatible system for subcutaneous drug delivery

Résumé

The aim of this study was to evidence the ability of vegetable oil-based hybrid microparticles (HMP) to be an efficient and safe drug delivery system after subcutaneous administration. The HMP resulted from combination of a thermostabilized emulsification process and a sol-gel chemistry. First of all, castor oil was successfully silylated by means of (3-Isocyanatopropyl)trimethoxysilane in solvent-free and catalyst-free conditions. Estradiol, as a model drug, was dissolved in silylated castor oil (ICOm) prior to emulsification, and then an optimal sol-gel crosslinking was achieved inside the ICOm microdroplets. The resulting estradiol-loaded microparticles were around 80 µm in size and allowed to entrap 4 wt% estradiol. Their release kinetics in a PBS/octanol biphasic system exhibited a one-week release profile, and the released estradiol was fully active on HeLa ERE-luciferase ERα cells. The hybrid microparticles were cytocompatible during preliminary tests on NIH 3T3 fibroblasts (ISO 10993-5 standard) and they were fully biocompatible after subcutaneous injection on mice (ISO 10993-6 standard) underlining their high potential as a safe and long-acting subcutaneous drug delivery system.

Domaines

Chimie
Fichier principal
Vignette du fichier
S0378517320310553.pdf (4.04 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03110144 , version 1 (02-01-2023)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Koceïla Doufène, Ilaria Basile, Aurélien Lebrun, Nelly Pirot, Aurélie Escande, et al.. Vegetable oil-based hybrid microparticles as a green and biocompatible system for subcutaneous drug delivery. International Journal of Pharmaceutics, 2021, 592, pp.120070. ⟨10.1016/j.ijpharm.2020.120070⟩. ⟨hal-03110144⟩
96 Consultations
17 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More