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Vegetable oil-based hybrid microparticles as a green and biocompatible system for subcutaneous drug delivery

Abstract : The aim of this study was to evidence the ability of vegetable oil-based hybrid microparticles (HMP) to be an efficient and safe drug delivery system after subcutaneous administration. The HMP resulted from combination of a thermostabilized emulsification process and a sol-gel chemistry. First of all, castor oil was successfully silylated by means of (3-Isocyanatopropyl)trimethoxysilane in solvent-free and catalyst-free conditions. Estradiol, as a model drug, was dissolved in silylated castor oil (ICOm) prior to emulsification, and then an optimal sol-gel crosslinking was achieved inside the ICOm microdroplets. The resulting estradiol-loaded microparticles were around 80 µm in size and allowed to entrap 4 wt% estradiol. Their release kinetics in a PBS/octanol biphasic system exhibited a one-week release profile, and the released estradiol was fully active on HeLa ERE-luciferase ERα cells. The hybrid microparticles were cytocompatible during preliminary tests on NIH 3T3 fibroblasts (ISO 10993-5 standard) and they were fully biocompatible after subcutaneous injection on mice (ISO 10993-6 standard) underlining their high potential as a safe and long-acting subcutaneous drug delivery system.
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https://hal.umontpellier.fr/hal-03110144
Contributeur : Icg Aigle <>
Soumis le : jeudi 14 janvier 2021 - 12:22:53
Dernière modification le : lundi 15 février 2021 - 13:29:04

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Koceïla Doufène, Ilaria Basile, Aurélien Lebrun, Nelly Pirot, Aurélie Escande, et al.. Vegetable oil-based hybrid microparticles as a green and biocompatible system for subcutaneous drug delivery. International Journal of Pharmaceutics, Elsevier, 2021, 592, pp.120070. ⟨10.1016/j.ijpharm.2020.120070⟩. ⟨hal-03110144⟩

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