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The CD133+ Stem/Progenitor-Like Cell Subset Is Increased in Human Milk and Peripheral Blood of HIV-Positive Women

Abstract : Human milk is a significant source of different CD133 + and/or CD34 + stem/progenitor-like cell subsets in healthy women but their cell distribution and percentages in this compartment of HIV-positive women have not been explored. To date, a decrease of CD34 + hematopoietic stem and progenitor cell frequencies in peripheral blood and bone marrow of HIV-positive patients has been reported. Herein, human milk and peripheral blood samples were collected between day 2-15 post-partum from HIV-positive and HIV-negative women, and cells were stained with stem cell markers and analyzed by flow cytometry. We report that the median percentage of CD45 +/high CD34 − CD133 + cell subset from milk and blood was significantly higher in HIV-positive than in HIV-negative women. The percentage of CD45 dim CD34 − CD133 + cell subset from blood was significantly higher in HIV-positive than HIV-negative women. Moreover, percentages of CD45 dim CD34 + , CD45 dim CD34 + CD133 − , and CD45 +high CD34 + CD133 − cell subsets from blood were significantly lower in HIV-positive than HIV-negative women. The CD133 + stem/progenitor-like cell subsets are increased in early human milk and blood of HIV-positive women and are differentially distributed to CD34 + cell subset frequencies which are decreased in blood.
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https://hal.umontpellier.fr/hal-03081897
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Soumis le : vendredi 18 décembre 2020 - 13:02:40
Dernière modification le : mercredi 3 novembre 2021 - 07:38:57
Archivage à long terme le : : vendredi 19 mars 2021 - 20:53:13

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Jacqueline María Valverde-Villegas, Mar Naranjo-Gomez, Mélusine Durand, David Rutagwera, Anne-Sophie Bedin, et al.. The CD133+ Stem/Progenitor-Like Cell Subset Is Increased in Human Milk and Peripheral Blood of HIV-Positive Women. Frontiers in Cellular and Infection Microbiology, Frontiers, 2020, 10, ⟨10.3389/fcimb.2020.546189⟩. ⟨hal-03081897⟩

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