Survey on Non-Human Primates and Mosquitoes Does not Provide Evidences of Spillover/Spillback between the Urban and Sylvatic Cycles of Yellow Fever and Zika Viruses Following Severe Outbreaks in Southeast Brazil - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Viruses Année : 2020

Survey on Non-Human Primates and Mosquitoes Does not Provide Evidences of Spillover/Spillback between the Urban and Sylvatic Cycles of Yellow Fever and Zika Viruses Following Severe Outbreaks in Southeast Brazil

Filipe Vieira Santos De Abreu
  • Fonction : Auteur
Anielly Ferreira-De-Brito
  • Fonction : Auteur
Adriana de Souza Azevedo
  • Fonction : Auteur
Vanessa de Oliveira Santos
  • Fonction : Auteur
Emily Hime Miranda
  • Fonction : Auteur
Ieda Pereira Ribeiro
  • Fonction : Auteur
Edmilson dos Santos
  • Fonction : Auteur
Taissa Pereira Dos Santos
  • Fonction : Auteur
Danilo Simonini Teixeira
  • Fonction : Auteur
Marcelo Quintela Gomes
  • Fonction : Auteur
Camilla Bayma Fernandes
  • Fonction : Auteur
Andrea Marques Vieira Da Silva
  • Fonction : Auteur
Monique da Rocha Queiroz Lima
  • Fonction : Auteur
Ana Paula Dinis Ano Bom
  • Fonction : Auteur
Luzia Maria De Oliveira-Pinto
  • Fonction : Auteur
Monique de Albuquerque Motta
  • Fonction : Auteur
Márcia Gonçalves Castro
  • Fonction : Auteur
Myrna Cristina Bonaldo
  • Fonction : Auteur
Sheila Maria Barbosa de Lima
  • Fonction : Auteur
Ricardo Lourenço-De-Oliveira
  • Fonction : Auteur

Résumé

In the last decade, Flaviviruses such as yellow fever (YFV) and Zika (ZIKV) have expanded their transmission areas. These viruses originated in Africa, where they exhibit both sylvatic and interhuman transmission cycles. In Brazil, the risk of YFV urbanization has grown, with the sylvatic transmission approaching the most densely populated metropolis, while concern about ZIKV spillback to a sylvatic cycle has risen. To investigate these health threats, we carried out extensive collections and arbovirus screening of 144 free-living, non-human primates (NHPs) and 5219 mosquitoes before, during, and after ZIKV and YFV outbreaks (2015–2018) in southeast Brazil. ZIKV infection was not detected in any NHP collected at any time. In contrast, current and previous YFV infections were detected in NHPs sampled between 2017 and 2018, but not before the onset of the YFV outbreak. Mosquito pools screened by high-throughput PCR were positive for YFV when captured in the wild and during the YFV outbreak, but were negative for 94 other arboviruses, including ZIKV, regardless of the time of collection. In conclusion, there was no evidence of YFV transmission in coastal southeast Brazil before the current outbreak, nor the spread or establishment of an independent sylvatic cycle of ZIKV or urban Aedes aegypti transmission of YFV in the region. In view of the region’s receptivity and vulnerability to arbovirus transmission, surveillance of NHPs and mosquitoes should be strengthened and continuous.
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hal-03002400 , version 1 (27-05-2021)

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Filipe Vieira Santos De Abreu, Anielly Ferreira-De-Brito, Adriana de Souza Azevedo, José Henrique Rezende Linhares, Vanessa de Oliveira Santos, et al.. Survey on Non-Human Primates and Mosquitoes Does not Provide Evidences of Spillover/Spillback between the Urban and Sylvatic Cycles of Yellow Fever and Zika Viruses Following Severe Outbreaks in Southeast Brazil. Viruses, 2020, 12 (4), ⟨10.3390/v12040364⟩. ⟨hal-03002400⟩
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