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A multiplex assay for the simultaneous detection of antibodies against 15 Plasmodium falciparum and Anopheles gambiae saliva antigens

Abstract : Assessment exposure and immunity to malaria is an important step in the fight against the disease. Increased malaria infection in non-immune travellers under anti-malarial chemoprophylaxis, as well as the implementation of malaria elimination programmes in endemic countries, raises new issues that pertain to these processes. Notably, monitoring malaria immunity has become more difficult in individuals showing low antibody (Ab) responses or taking medications against the Plasmodium falciparum blood stages. Commonly available techniques in malaria seroepidemiology have limited sensitivity, both against pre-erythrocytic, as against blood stages of the parasite. Thus, the aim of this study was to develop a sensitive tool to assess the exposure to malaria or to bites from the vector Anopheles gambiae, despite anti-malarial prophylactic treatment.
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https://hal.umontpellier.fr/hal-02991300
Contributeur : Anne Poinsignon <>
Soumis le : jeudi 5 novembre 2020 - 22:56:10
Dernière modification le : jeudi 3 décembre 2020 - 17:00:02

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Elena Ambrosino, Chloé Dumoulin, Eve Orlandi-Pradines, Franck Remoue, Aissatou Toure-Baldé, et al.. A multiplex assay for the simultaneous detection of antibodies against 15 Plasmodium falciparum and Anopheles gambiae saliva antigens. Malaria Journal, BioMed Central, 2010, 9 (1), pp.317. ⟨10.1186/1475-2875-9-317⟩. ⟨hal-02991300⟩

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